Ramos and Pique have frequently clashed publicly and that was the case again on Tuesday, despite being in camp together following Spain's 2-0 global friendly win over France.
Marca reports that Madrid are considering taking legal action against the Spain global, who also said he does not like that those in the "Real box seat pull the country's strings".
The defender has subtly claimed that Real Madrid president Florentino Perez has used his powerful position at the club to obtain diverse favours and even questioned why both Messi and Neymar face allegations - referring to their legal battles.
I consider all of Madrid's players friends, but as a club, what do you want me to say?
Sergio Ramos is a real talisman for Real Madrid and he has allowed them to gain upwards of 100 million euros over the past 4-5 seasons because of his timely goals.
Spain's supreme court scheduled a hearing for the appeal of Messi and his father Jorge against a 21-month prison sentence for tax fraud on April 20, three days before Barca take on Madrid, according to reports.
'I have huge appreciation for the players that they have and some of them are my friends.
"We all know what goes on in the Madrid box, it's always been like that". Charges against Messi, Neymar....nothing against Cristiano.
"Joining Barcelona? This is football, and you can never say that "I will not do this or that". "If we start talking about everything. what about Iniesta (who scored a controversial victor against Chelsea in the 2009 Champions League semi-final). they are not the ones to talk, they are not".
The 39-year-old won six La Liga titles and the Champions League three times and he has regularly spoken about his desire to return to the Spanish capital in the future.