A friend, speaking on behalf of the family, said Kenley Ratliff loved spending time outdoors with her family.
Kenley died last Saturday, several days after being admitted to the Riley Hospital for Children, WISH-TV reported.
Kirby said the doctors tried treating Kenley for Rocky Mountain Spotted Fever as best as they could.
Kenley was admitted to the hospital Tuesday after her high fever didn't break.
Kirby says their diagnosis was Rocky Mountain Spotted Fever.
"I'm so thankful that I got to spend the two years and Kayla's thankful she even had the two years she had with her daughter", said Clapp. Her mother rushed her to the hospital. "Her little two-year-old hand was just so swollen it was nearly the size of her mother's".
"She would be devastated to see this to happen to anyone else and I think she would just, she would just everyone to know how much she loved her baby girl that was her angel", Kirby said. "They're wanting to raise awareness for others, so this doesn't happen to them".
The state health department said it had 40 cases of the disease in 2016. "By then, her brain was so swollen from the weeklong fever".
Rocky Mountain spotted fever got its name because the first cases cropped up in people bitten by ticks in and around the Rocky Mountains, and "spotted" refers to the rash many patients get.
A tick bite is likely what led to the death of an energetic two-year-old in Plainfield over the weekend. If not treated right away with antibiotics, there is a high death rate associated with the disease.
Symptoms include fever, headache, abdominal pain, vomitting and muscle pain.
Summer is almost here, and it's bringing fears of a rare tick-borne disease called Powassan.
Keeping grass trimmed and plants cropped around homes are good practices to prevent ticks.