Cueto had a rocky outing on the last day of the season, allowing four runs and 12 hits in five innings. Cain made the final appearances of his 13-year career Saturday. Jhoulys Chacin went six innings, giving up one run on five hits, walking a pair and striking out six, not factoring in the decision.
"It's nice to have a young man like this come up and make some noise to where he wants to be in this rotation right now", Giants manager Bruce Bochy said of Stratton's late-season starts.
Following the season's final game, the last of Matt Cain's career, the career Giant offered fans and teammates an emotional farewell to his 13-year career in the City by the Bay.
The Padres (71-91) lost for the sixth time in seven games as they concluded their seventh straight losing season with a modest improvement of three more wins than last season.
Sandoval, 31, rejoined the Giants in July, a few days after the Red Sox released him.
The Giants hadn't won a series with the Padres since the 2016 All-Star break, losing seven of eight with one series tie over that stretch. The 24-year-old right-hander threw a season-high 108 pitches. Sandoval finished 1-for-4 on the afternoon, also knocking in a run in the second on a ground out.
Buddy Baumann (2-1), who pitched a scoreless eighth inning, got the win. Cueto, like most Giants' starters, didn't receive much help from his defense, as outfielders played a part in allowing the first four hitters of the game to reach with base hits. Buster Posey, the fifth overall pick in the 2008 draft, hit cleanup and smashed a leadoff double in the bottom of the second and then drew a walk in the bottom of the fourth.