It would not be an easy target for the Indian shuttler to defeat former world no. 1 Intanon who enjoys an upper hand over Sindhu.
The Hong Kong Open Superseries women's singles had been continuing on expected lines - with seven out of eight seed making it to the quarter finals - with just one surprising exit.
The second seed took 37 minutes to beat world no.2 Akane 21-12, 21-19 in the quarter-finals at the Hong Kong Coliseum.
After compatriots, Saina Nehwal and HS Prannoy crashed out of the Hong Kong Open Superseries in the second round of the badminton championship - Pusarla Venkata sindhu stands as the sole Indian to continue dominance in the tournament. Sindhu was in supreme form and maintained a lead right from the start.
Sindhu will be up against sixth seed Ratchanok Intanon of Thailand, who earlier beat Canada's Michelle Li 21-14, 21-16, in the semi-finals.
Yamaguchi and Sindhu have met seven times in their careers; Sindhu leads the head-to-head with four wins to Yamaguchi's two. Also, this will be their first meeting this year.
China's Chen Yufei, seeded eighth, put out Saina 18-21, 21-19, 21-10 in an encounter that lasted an hour, while Prannoy went down 11-21, 21-10, 21-15 against Japan's Kazumasa Sakai. He squandered three match points to slump to a 21-15, 9-21, 20-22 defeat to the World No. 52 Lee Dong Keun of Korea.