Bryant stated, "As basketball players we're really supposed to shut up and dribble, but. we do a bit more than that".
When he was 24 years old, Bryant was accused of sexual assault by a 19-year-old employee of an Edwards, Colorado hotel in which he was staying.
The criminal case was dropped when the accuser refused to testify, but Bryant faced a civil suit.
Bryant then thanked those involved in the film along with his family. Some noted that with past rape accusations against Bryant, his appearance seemed an odd fit with the night's Time's Up anti-harassment theme.
Sadly, Shaq's performance in "Kazaam" did not net him an Oscar.
Awards prediction website Gold Derby had Bryant as the odds-on favourite to win the Oscar for best animated short, but his triumph is unlikely to please everyone.