The late-night funnyman's quips, however, came on the same day that Mrs. Trump was seen sitting next to her husband President Donald Trump during a solemn White House ceremony in which Gold Star Families were honored.
The first ladysaid in a written statement after last June's event that these families "are a unique and distinct category of individuals who should be cherished".
Shortly afterwards, she entered Walter Reed National Military Medical Center for what the White House described as a benign kidney procedure.
Mrs. Trump is scheduled to join the president Monday in hosting a reception, closed to the press, for Gold Star families.
"To all those who have lost loved ones in service to our country, our nation grieves with you", her statement said.
Mrs Trump made her worldwide debut as first lady at last year's G7 summit in Italy, and went on to attend the G20 in Germany.
The 48-year-old has not been seen since Thursday, May 10, when she, along with President Donald Trump, welcomed home three Americans who had been held captive by North Korea. However, the first lady's absence made her appearance all the more newsworthy.
Earlier that day, Ms Grisham said the first lady had been working on projects including a picnic and having meetings with staff.