The English club sit top of Group C after beating Paris Saint-Germain 3-2 in their opener while the Italians were held 0-0 at Red Star Belgrade.
Napoli are joint second with FK Crvena Zvezda after both teams drew 1-1 last time out.
Egyptian Mohamed Salah continues to struggle for form, on a weekend of Premier League action which saw his Liverpool side drop points for the first time and lose top spot on the log to champions Manchester City.
It certainly promises to be an interesting encounter as Napoli take on Liverpool. The result was disappointing for Napoli, who entered the game knowing if they wanted to end Juventus' Serie A dominance, they needed to win.