Clinton doesn't respond to this quip, but she does light up when the comedian says, "Let's talk about Trump". "You need to get out more", Clinton responded.
"What happens if you become pregnant? he asks the sexagenarian candidate. Are we gonna be stuck with Tim Kaine for nine-months?" "How does this work?"
Why would you interrupt me with an ad for my opponent, Clinton asked.
"I assume he will wear that red power tie", Clinton says. "Or maybe like a White Power tie?"
If Clinton is playing along, then you have to give her credit for her sense of humor.
In the clip, you'll notice the show uses a chyrons to identify Clinton as someone who "had pneumonia". The move for her is a smart one as it lends her to appeal further with young voters. "We didn't have to go through the hoops we sometimes have to go through in order to even get Hollywood people to do it". The Democratic nominee filmed the appearance at New York Historical Society on September 9 - the same day she was diagnosed with pneumonia.
The Hangover star asks the Democratic nominee for this year's election a number of awkward questions, including a grilling on her flip-flop over the controversial Trans-Pacific Partnership (TPP) deal. But we're glad she did.
This follows Republican candidate Donald Trump's appearance on "The Dr. Oz Show" last week, in which he released his medical records. "A lot of times with "Between Two Ferns" if it's someone in entertainment, their publicist will reach out".
"Tell me, when you first laid eyes on Angelina [Jolie], is it like one of those classical love stories, like when Ross first saw Rachel?"